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Annotations show territorial variabilities that are noted in the Tatu et al atlas. Color blending was performed for interterritorial overlap areas. Cing, posterior cingulate gyrus PCL, paracentral lobule PrCu, precuneus Rectus, gyrus rectus Rop, rolandic operculum AOS, anterior occipital sulcus CS, central sulcus IFS, inferior frontal sulcus IPS, intraparietal sulcus LF, lateral fissure MTS, middle temporal sulcus PrCS, precentral sulcus PoCS, postcentral sulcus SFS, superior frontal sulcus STS, superior temporal sulcus TOS, temporooccipital sulcus Am, amygdala Ca, caudate GP, globus pallidus Ins, Insula Put, putamen SMA, supplementary motor area SOS, superior occipital sulcus Spl, splenium Thal, thalamus.Ī, Voxelwise lesion frequency heatmaps were generated using diffusion-weighted magnetic resonance imaging data of patients with acute ischemic stroke admitted with anterior/middle/posterior cerebral artery (ACA, MCA, and PCA) infarction associated with significant stenosis or occlusion of a relevant large artery (N = 1160). Cing, middle cingulate gyrus Olf, olfactory gyrus P. Cing indicates anterior cingulate gyrus GA, angular gyrus Cal, calcarine gyrus Cu, cuneus GF, fusiform gyrus GFd, medial frontal gyrus GFdo, orbital part of the medial frontal gyrus GFsd, superior part of the medial frontal gyrus GFi, inferior frontal gyrus GFio, orbital part of the inferior frontal gyrus GFiop, opercular part GFit, triangularis GFm, middle frontal gyrus GFmo, orbital part of the middle frontal gyrus GFs, superior frontal gyrus GFso, orbital part of the superior frontal gyrus GH, Heschl gyrus GpH, parahippocampal gyrus GL, lingual gyrus GOi, inferior occipital gyrus GOm, middle occipital gyrus GOs, superior occipital gyrus GPoC, postcentral gyrus GPrC, precentral gyrus GSM, supramarginal gyrus GTs, superior temporal gyrus GTps, temporal pole GTi, inferior temporal gyrus GTm, middle temporal gyrus LPi, inferior parietal lobule LPs, superior parietal lobule M. This pipeline is widely applicable to different experimental paradigms, including animal species for which transgenic activity reporters are not readily available.The Montreal Neurological Institute ch2better-templates and the Automated Anatomical Atlas 20 were used to display anatomic information in the supratentorial brain: z = −14.5 mm (section 13), −8.5 mm (section 14), −2.5 mm (section 15), 3.5 mm (section 16), 9.5 mm (section 17), 15.5 mm (section 18), 21.5 mm (section 19), 27.5 mm (section 20), 33.5 mm (section 21), 39.5 mm (section 22), 45.5 mm (section 23) mm, and 51.5 mm (section 24) superior to the reference axial plane: anterior commissure–posterior commissure plane. Last, we combine activity mapping with axon tracing to uncover new brain regions differentially activated during parenting behavior. Next, we report new cortical regions downstream of whisker-evoked sensory processing during active exploration. We validate the pipeline first by analysis of brain regions activated in response to haloperidol.
Figure permissions human brain mapping software#
We introduce a pipeline for high-speed acquisition of brain activity at cellular resolution through profiling immediate early gene expression using immunostaining and light-sheet fluorescence imaging, followed by automated mapping and analysis of activity by an open-source software program we term ClearMap.
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Understanding how neural information is processed in physiological and pathological states would benefit from precise detection, localization, and quantification of the activity of all neurons across the entire brain, which has not, to date, been achieved in the mammalian brain.